Alzheimer's disease is a 21st century epidemic that currently affects more than 35 million people worldwide, with this number estimated to rise to 82 million by 2030. The fifth leading cause of death globally and the most common cause of dementia, Alzheimer's costs society upwards of $818 billion a year; yet despite significant research and investment, it remains an incurable disease.

Grifols' research into Alzheimer's began with a small clinical study into the potential of plasma exchange with albumin to slow the progression of the disease in mild and moderate AD patients.

More than a decade later, this research has become a phase IIb/III clinical trial: AMBAR, Alzheimer Management by Albumin Replacement.

The AMBAR clinical trial has been carried out in 41 hospitals across the U.S. and Spain, in collaboration with some of the world's leading Alzheimer's research centers and organizations.

In October 2018 we presented primary outcomes of the AMBAR study (phase IIb/III) at the Clinical Trials on Alzheimer's Disease (CTAD) congress, hold in Barcelona. In 2019 we plan to present new results at other global congresses including the Alzheimer's Association International Conference (AAIC) in July and this year's edition of the CTAD, which will be held in December.

+ 35 million

people world-wide suffer from Alzheimer's disease (AD)

14 years

of research on AD

+ €150 million

invested in AD research since 2004

Alzheimer's Disease

It is currently estimated that 35 million people worldwide suffer from Alzheimer's, and this figure is continuing to grow.

Read more

Grifols and Alzheimer's

Since 2004, we have led a broad range of research initiatives on Alzheimer's.

Read more

The AMBAR hypothesis

AMBAR is an innovative treatment proposal aimed at slowing the progression of Alzheimer's disease through periodic plasma exchange.

Read more


AMBAR is an international and multicenter clinical trial designed by Grifols in collaboration with Fundació ACE in Barcelona, Spain; and the Alzheimer Disease Research Center in Pittsburgh, PA, U.S.

Read more


The results

The new results of AMBAR, an innovative treatment approach for Alzheimer's disease (AD) using plasma science, show that both mild and moderate patients improve after treatment.