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Analysis flebula with elastic stopper

The devices that overcame sepsis

Technical file

Innovation leader: Josep Antoni Grífols i Roig

Year: 1916

Period: Origins (1909-1939)

Type of innovation: Instrument

Scope: Clinical analysis

Patent: Yes

Geographical reach: National

Economic impact:  3-Low

Level of innovation:  1-Disruptive

Interdisciplinary connections: -

Related innovations: Transfusion flebula, Control sera and the ABO blood typing system, Indirect transfusion

Josep Antoni Grífols i Roig crowned his specialization in the field of clinical analysis with the establishment of the Instituto Central de Análisis Clínicos, a clinical analysis laboratory in Barcelona ​​in 1909.

It was here that his twin passions of diagnostic and therapeutic medicines converged in a way that was to lay the foundations of the company that would bear the family name.

 

The third great passion

It was also here that the key practical challenges of the day came into sharp focus. Chief among these was maintaining the sterility of samples, even when sent out to laboratories for testing. It was a challenge that was to add a third element to Grífols i Roig's expertise–technological innovation.

The fruits of that innovation were prolific. During these first years of his clinic he created eight different scientific instruments, the great majority of them destined to obtain blood samples in conditions of absolute asepsis, and always with minimal pain for the patient.

 

Making blood samples routine

Chief among these early inventions was his clinical analysis device, known as the analysis flebula. Patented in 1916 and incrementally refined until 1929, the device ensured that taking samples for blood testing could become a straightforward routine task for any doctor. It also guaranteed that any sample taken with the device would arrive at the analysis lab in an aseptic, uncontaminated condition.

The proof of its effectiveness–and the far-sightedness of its inventor–is that more than twenty years later an American company, Becton Dickinson, patented the Vacutainer, a device very similar to the analysis flebula. What's more, the instrument was an unqualified commercial success.

 

 

The search for sterility which drove technical innovation.

 

Bibliography

  • Grífols Roig, J.A. (1913). Contribución al perfeccionamiento del método y técnica de la Reacción de Wassermann . (Tesis doctoral). Depositada en la Universidad de Barcelona.
  • Moragas, R. (1913). La reacció aglutinant com a medi diagnòstic de les malalties infeccioses. Actes, ponència i comunicacions del Primer Congrés dels Metges de Llengua Catalana , 331-379.
  • Moragas, R. i Grífols Roig, J.A. (1914). Presentació d'un nou aparell per hemocultius aerobis i anaerobis. Anals de l'Acadèmia y Laboratori de Ciències Mèdiques de Catalunya , vol. 9, 423-427.
  • Moragas, R. i Grífols Roig, J.A. (1915). Presentació d'un tub de fermentació per a cultius, aplicable a la investigació del coli en les aigües. Anals de l'Acadèmia y Laboratori de Ciències Mèdiques de Catalunya, vol. 10 , 77-79.
  • Grífols Roig, J. A. (1916). Un aparato perfeccionado para la obtención de muestras de sangre, destinadas al análisis. Patente de invención no. 62983. Madrid, España: Oficina Española de Patentes.
  • Grífols Roig, J.A. (1917). Aparell per a l'extracció de sang per diferents anàlisis . Anals de l'Acadèmia y Laboratori de Ciències Mèdiques de Catalunya. 238-241.
  • Grífols Roig, J.A. (1919). Tractament de les septicèmies estafilocòciques d'origen no quirúrgic ni puerperal. Tercer Congrés de Metges de Llengua Catalana, 601-610.
  • Moragas, R., & Grífols Roig, J.A. (1919). Discussió. Tercer Congrés de Metges de Llengua Catalana, 72-73.
  • Grífols Roig, J. A. (1926). Un aparato perfeccionado para la obtención de muestras de sangre y de otros fluidos del organismo humano y animal, destinadas al análisis serológico, químico, citológico y bacteriológico. Patente de invención no. 100040. Madrid, España: Oficina Española de Patentes.
  • Grífols Roig, J. A. (1927). Perfeccionamiento de un aparato perfeccionado para la obtención de muestras de sangre y de otros fluidos del organismo humano y animal, destinadas al análisis serológico, químico, citológico y bacteriológico. Certificado de adición no. 104847. Madrid, España: Oficina Española de Patentes
  • Grifols Roig, J. A. (1928). Modelo de tapón elástico para tubos, frescos o botellas. Certificado de Modelos y dibujos no. 6030. Madrid, España: Oficina Española de Patentes y Marcas.
  • Grifols Roig, J. A. (1929). Ampollas previamente preparadas auto-aspiradoras y auto-inyectables. Patente de invención no. 111456. Madrid, España: Oficina Española de Patentes y Marcas.
  • Baños, J.E., & Guardiola, E. (2017). Eponímia mèdica catalana. Les flèbules de Grífols. Annals de Medicina, 100(2), 87-90.