The results

The AMBAR trial has demonstrated a significant reduction in the progression of Alzheimer's in moderate patients.

AMBAR, an innovative treatment approach for Alzheimer's disease (AD) based on the combination of Plasmapheresis with Albutein® 20% replacement under development in phase IIb/III, may offer a new treatment pathway for the illness in the future.

Press release

Grifols AMBAR results demonstrate a significant reduction in the progression of moderate Alzheimer's Disease


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"Grifols will continue to explore the potential of plasma proteins and plasma exchange in further studies."

Víctor Grífols, Grifols Chairman

"The results are positive and highly relevant in a cohort of patients suffering from moderate Alzheimer disease."

Antonio Páez, M.D., Grifols Medical Director and Head of the AMBAR Clinical Program

"This is the most significant development in the treatment of patients with moderate Alzheimer's disease I've seen in over 15 years."

Mercè Boada, M.D., Ph.D., Director of Fundació ACE.

"Those findings open new avenues for the research of neurodegenerative disorders that have the potential to offer a new modality of treatment."

Dr. Óscar López, Director of the AD Research Center of the University of Pittsburgh

AMBAR in the media:

Nature: International journal of science

Alzheimer's Disease

It is currently estimated that 35 million people worldwide suffer from Alzheimer's, and this figure is continuing to grow.

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Grifols and Alzheimer's

Since 2004, we have led a broad range of research initiatives on Alzheimer's.

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The AMBAR hypothesis

AMBAR is an innovative treatment proposal aimed at slowing the progression of Alzheimer's disease through periodic plasma exchange.

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The AMBAR
study

AMBAR is an international and multicenter clinical trial designed by Grifols in collaboration with Fundació ACE in Barcelona, Spain; and the Alzheimer Disease Research Center in Pittsburgh, PA, U.S.

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