Machinery Development
We develop machinery and robotic systems to enhance manufacturing processes. Our experience in the biopharmaceutical industry enables us to understand your needs and offer optimal service.
Tailor-made Solutions
Development of highly specific machine prototypes that are not otherwise commercially available. Designed to obtain validation for biopharmaceutical facilities, sterile processes and aseptic zones.
Robotic reagent filling production lines
Totally automated production lines for filling diagnostic reagents cards.
- Increased yield
- Increased filling quality
- Can be adapted to different formats
Polypropylene cap assembly machines for bags of parenteral solutions
Fully automated lines for the assembly of caps.
- Automated 3-piece cap assembly machine
- 3,000 pieces/hour. PLC-controlled and touchscreen operated
Pharmaceutical Robotics
Robotics to automate process lines to minimize possible external contamination and reduce costs.
Bag- and bottle-thawing and emptying line for plasma and other biotech products.
PBO: Plasma Bag Opener
Grifols Engineering plasma bag opener (PBO) is designed to perform the following tasks:
- The frozen plasma inside the bag is skin-thawed to create a liquid film inside the bag
- The outer surface of the bag is then rinsed with fresh deionized (DI) water or water for injection (WFI), removing any particles adhered to it
- The outer surface of the bag is then dried to start the manufacturing process
- A robotic system cuts the plasma bag and the plasma is removed from the bag and transferred to the processing tank
ABO: Automatic Bottle Opener
The Automatic Bottle Opener (ABO) is a thawing tunnel and plasma bottle washing and cutting and handling line designed by Grifols Engineering to perform series of sequential tasks:
- The frozen plasma inside the bottle is skin-thawed to create a liquid film inside the bottle
- The outer surface of the plastic bottle is rinsed with fresh deionized (DI) water or water for injection (WFI), removing any particles adhered to it
- The outer surface is dried with air jets
- The bottle is automatically cut, the plasma is separated from the bottle and the product is transferred to the processing tank
PBS: Plasma Bottle Sampling
Plasma Bottle and Bag Sampling (PBS) is a patented system designed and manufactured by Grifols Engineering. It provides added accuracy and safety during manipulation of plasma samples.
PCM: Plasma Cutting Machine
The Plasma Cutting Machine (PCM) is a patented system designed and manufactured by Grifols Engineering. It provides a high level of safety as the plasma is not handled by the operator while the bottles and bags are cut, minimizing possible external contamination, reducing costs and increasing yield.

Machinery - Pharmaceutical Robotics
Standardized Processes
We develop machinery for standardized aseptic liquid dosing processes and machines for dosing parental solutions in bags.
Sterile filling of liquids: G.S.F® (Grifols Sterile Filling)
Grifols Sterile Filling Systems provide a different approach to conventional aseptic filling. G.S.F® minimizes the potential risk of airborne particle contamination during filling, ensuring the maximum quality of the product.
- Unique patented process for filling liquid products in sterile conditions
- Global solution: preparation and sterilization system of components, handling, sterile filling, process control and vial laser etching
- More than 15 years of proven reliability in sterile filling
Main Advantages:
- Vial is closed and protected throughout the process
- Vial is opened in the final filling stage in a controlled environment with horizontal laminar flow
- Sterilization and depyrogenation combined with HWFI is a washing cycle followed by autoclave cycle, eliminating the need for a dry heat tunnel
Grifols Robotic Filling Line (GRFL®)
Automatic production line for aseptic liquid with secondary filling, stoppering, sealing and laser etching.
Bag-filling machines
Automated and semi-automated sterile filling machines for filling and capping flexible bags with pharmaceutical solutions, in compliance with the strict requirements of Good Manufacturing Practices (GMP).
Creative and tailor-made solutions for the biotech and parenteral nutrition market.
¿How can we help you?
For general, commercial, and technical inquiries, please contact the Grifols Engineering team directly.
Experience you can count on
Engineering
We develop our own biopharmaceutical projects to solve production needs in accordance with the strictest standards of the EU health authorities and the U.S. FDA.
Consulting
We provide design analysis and technical studies to ensure compliance with the strictest regulatory standards in the pharmaceutical industry.